{"id":13345,"date":"2025-10-08T16:24:21","date_gmt":"2025-10-08T12:54:21","guid":{"rendered":"https:\/\/ap-rad.com\/product\/braf-v600e-mutation-real-time-pcr-kit\/"},"modified":"2025-10-08T16:24:21","modified_gmt":"2025-10-08T12:54:21","slug":"braf-v600e-mutation-real-time-pcr-kit","status":"publish","type":"product","link":"https:\/\/ap-rad.com\/en\/product\/braf-v600e-mutation-real-time-pcr-kit\/","title":{"rendered":"BRAF V600E Mutation Real Time PCR Kit"},"content":{"rendered":"

BRAF V600E Mutation Real Time PCR Kit<\/b><\/h1>\n

The BRAF<\/b> gene encodes a serine\/threonine kinase<\/b> that plays a key role in the Mitogen-Activated Protein Kinase (MAPK)<\/b> signaling pathway. This pathway is one of the most important signaling cascades regulating cell growth, division, and programmed cell death<\/b>, and its disruption can lead to uncontrolled cell proliferation and tumor formation.<\/p>\n

The most common genetic alteration in this gene is the V600E mutation<\/b>. This mutation results from a point mutation (T1799A)<\/b> in codon 600 of exon 15<\/b> on chromosome 7, leading to the substitution of valine with glutamic acid<\/b> at this position (p.Val600Glu<\/b>). This amino acid change causes constitutive activation of the MAPK pathway<\/b>, resulting in increased cell proliferation, tumor invasion, and resistance to apoptosis<\/b>.<\/h3>\n

The BRAF V600E<\/b> mutation is associated with a wide range of malignancies, including:<\/p>\n

    \n
  • Melanoma<\/b><\/li>\n
  • Colorectal cancer<\/b><\/li>\n
  • Papillary thyroid carcinoma (PTC)<\/b><\/li>\n
  • Multiple myeloma<\/b><\/li>\n
  • Lung cancer<\/b><\/li>\n<\/ul>\n

    The importance of this mutation is not limited to diagnosis; it also plays a critical role in prognosis<\/b> and targeted therapy selection<\/b>. Accurate identification of this mutation can significantly impact treatment decisions, prediction of patient response to therapy, and disease monitoring<\/b>.<\/p>\n

    ap-rad<\/b>, based on proprietary design, has developed the BRAF V600E Mutation Real Time PCR Kit<\/b>. This kit is designed for:<\/p>\n

      \n
    • Rapid, sensitive, and highly specific detection<\/b> of the BRAF V600E mutation<\/li>\n
    • Precise differentiation<\/b> between wild-type and mutated forms<\/li>\n
    • Application in molecular diagnostics, disease prognosis, and targeted therapy selection<\/b><\/li>\n<\/ul>\n

      This kit provides an accurate tool for molecular genetics laboratories and cancer diagnostic centers.<\/p>\n","protected":false},"excerpt":{"rendered":"

        \n
      • Results obtained in the shortest possible time (75 minutes)<\/li>\n
      • 100% diagnostic sensitivity and specificity<\/li>\n
      • Contains internal, positive, and negative controls to confirm the extraction process and PCR test<\/li>\n<\/ul>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"en_name":"","footnotes":""},"product_brand":[],"product_cat":[2485],"product_tag":[2655,2566,2565,2654,2683,2567,2764,2763,2758,2759,2761,2753,2756,2765,2754,2762,2755,2760,2757,2767,2768,2529,2524,2523,2766],"class_list":{"0":"post-13345","1":"product","2":"type-product","3":"status-publish","5":"product_cat-genomic-kits","6":"product_tag-amir-peyvand","7":"product_tag-amirpeyvand","8":"product_tag-ap-rad","9":"product_tag-ap-rad-2","10":"product_tag-ap-rad-3","11":"product_tag-aprad","12":"product_tag-braf-detection-kit","13":"product_tag-braf-laboratory-kit","14":"product_tag-braf-mutation","15":"product_tag-braf-mutation-detection-kit","16":"product_tag-braf-real-time-pcr-kit","17":"product_tag-braf-v600e","18":"product_tag-braf-v600e-detection","19":"product_tag-braf-v600e-gene-test","20":"product_tag-braf-v600e-kit","21":"product_tag-braf-v600e-molecular-kit","22":"product_tag-braf-v600e-mutation","23":"product_tag-braf-v600e-mutation-detection-kit","24":"product_tag-braf-v600e-real-time-pcr","25":"product_tag-braf-associated-cancer","26":"product_tag-braf-associated-cancer-diagnosis","27":"product_tag-detection-kit","28":"product_tag-diagnosis","29":"product_tag-kit","30":"product_tag-melanoma","31":"pa_certificates-ruo","32":"pa_rxn-25r","34":"first","35":"instock","36":"shipping-taxable","37":"product-type-simple"},"yoast_head":"\nBRAF V600E Mutation Detection Kit - ap-rad<\/title>\n<meta name=\"description\" content=\"\u0634\u0631\u06a9\u062a \u067e\u0698\u0648\u0647\u0634 \u0648 \u062a\u0648\u0633\u0639\u0647 \u0627\u0645\u06cc\u0631\u067e\u06cc\u0648\u0646\u062f (AP-RAD) \u0628\u0627 \u0628\u0647\u0631\u0647\u200c\u06af\u06cc\u0631\u06cc \u0627\u0632 \u0641\u0646\u0627\u0648\u0631\u06cc Real-Time PCR \u0648 \u0637\u0631\u0627\u062d\u06cc \u0627\u062e\u062a\u0635\u0627\u0635\u06cc \u067e\u0631\u0627\u06cc\u0645\u0631 \u0648 \u067e\u0631\u0648\u0628\u060c **\u06a9\u06cc\u062a \u062a\u0634\u062e\u06cc\u0635 \u062c\u0647\u0634 BRAF V600E** \u0631\u0627 \u062c\u0647\u062a \u062a\u0634\u062e\u06cc\u0635 \u0633\u0631\u06cc\u0639\u060c \u062d\u0633\u0627\u0633 \u0648 \u0627\u062e\u062a\u0635\u0627\u0635\u06cc \u0627\u06cc\u0646 \u062c\u0647\u0634 \u0637\u0631\u0627\u062d\u06cc \u0648 \u062a\u0648\u0644\u06cc\u062f \u0646\u0645\u0648\u062f\u0647 \u0627\u0633\u062a.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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