{"id":13361,"date":"2025-05-18T16:16:08","date_gmt":"2025-05-18T12:46:08","guid":{"rendered":"https:\/\/ap-rad.com\/product\/fvl-fii-genotyping-real-time-pcr-kit\/"},"modified":"2025-05-18T16:16:08","modified_gmt":"2025-05-18T12:46:08","slug":"fvl-fii-genotyping-real-time-pcr-kit","status":"publish","type":"product","link":"https:\/\/ap-rad.com\/en\/product\/fvl-fii-genotyping-real-time-pcr-kit\/","title":{"rendered":"FVL &#038; FII Genotyping Real Time PCR Kit"},"content":{"rendered":"<h1>FVL &#038; FII Genotyping Real Time PCR Kit | Factor V Leiden and Factor II Genotyping Real Time PCR Detection Kit<\/h1>\n<p><b>ap-rad<\/b> product designed and manufactured for <b>rapid, sensitive, and specific detection of two important SNPs associated with hereditary thrombophilia: G506A in the FVL gene (Factor V Leiden) and G20210A in the FII gene (Prothrombin)<\/b>.<\/p>\n<p><b>Thrombophilia<\/b> refers to a group of inherited or acquired disorders that predispose an individual to blood clot formation. Affected individuals are at increased risk for <b>VTE (Venous Thromboembolism)<\/b> disorders including <b>deep vein thrombosis (DVT)<\/b> and <b>pulmonary embolism (PE)<\/b>.<\/p>\n<h3><b>Acquired Thrombophilia<\/b><\/h3>\n<p>This type usually occurs under the following conditions:<\/p>\n<ul>\n<li>Prolonged hospitalization after surgery<\/li>\n<li>Injuries and trauma to the lower limbs<\/li>\n<li>Certain types of cancer<\/li>\n<li>Prolonged immobilization<\/li>\n<\/ul>\n<h3><b>Hereditary Thrombophilia<\/b><\/h3>\n<p>The most important genetic causes are the following two mutations, inherited from parents:<\/p>\n<ul>\n<li><b>Factor V Leiden (G506A)<\/b><\/li>\n<li><b>Factor II \/ Prothrombin (G20210A)<\/b><\/li>\n<\/ul>\n<p>Both genes are key factors in the blood coagulation pathway.<\/p>\n<ul>\n<li>The <b>FII mutation (G20210A)<\/b> is associated with <b>increased prothrombin production<\/b> and enhances blood clotting ability.<\/li>\n<li>The <b>FVL mutation (G506A)<\/b> causes <b>structural changes in Factor V<\/b>, making it resistant to the &#8220;protein inhibitor factor&#8221;; therefore, the coagulation process increases abnormally.<\/li>\n<\/ul>\n<h3><b>Prevalence and Clinical Significance<\/b><\/h3>\n<ul>\n<li><b>FVL<\/b> is the most common hereditary cause of thrombophilia and affects <b>1 to 5 percent<\/b> of the population.<\/li>\n<li><b>Heterozygous<\/b> individuals for one of these two mutations are at <b>moderate risk<\/b>.<\/li>\n<li>Individuals <b>heterozygous for both genes simultaneously<\/b> are up to <b>20 times<\/b> more susceptible to thrombosis.<\/li>\n<li><b>Homozygotes<\/b> for both genes are very rare but have the highest level of risk.<\/li>\n<\/ul>\n<h3><b>Kit Application<\/b><\/h3>\n<p>The <b>FVL &#038; FII Genotyping Real-Time PCR Kit<\/b> enables <b>simultaneous detection of two key SNPs, G506A and G20210A<\/b>, with high accuracy and is an effective tool for:<\/p>\n<ul>\n<li>Thrombosis risk assessment<\/li>\n<li>Evaluation of patients with a family history of VTE<\/li>\n<li>Differential diagnosis of hereditary thrombophilia alongside acquired causes<\/li>\n<li>Decision-making regarding anticoagulant therapies<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li>100% diagnostic sensitivity and specificity<\/li>\n<li>Contains Wild Type and heterozygous controls for FVL &#038; FII factors to confirm the extraction process and PCR test<\/li>\n<li>Results obtained in the shortest possible time (90 minutes)<\/li>\n<\/ul>\n","protected":false},"featured_media":13360,"comment_status":"open","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"en_name":"","footnotes":""},"product_brand":[],"product_cat":[2485],"product_tag":[2917,2918,2924,2529,2920,2923,2921,2922,2897,2898,2899,2900,2893,2901,2906,2907,2911,2908,2902,2903,2904,2910,2909,2894,2895,2896,2905,2919,2915,2916,2914,2925,2912,2913],"class_list":{"0":"post-13361","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-genomic-kits","7":"product_tag-anticoagulant-detection-kit","8":"product_tag-anticoagulant-kit","9":"product_tag-blood-coagulation-detection-kit","10":"product_tag-detection-kit","11":"product_tag-factor-v","12":"product_tag-factor-v-and-prothrombin-detection-kit","13":"product_tag-factor-v-detection-kit","14":"product_tag-factor-v-kit","15":"product_tag-fii","16":"product_tag-fii-kit","17":"product_tag-fii-pcr","18":"product_tag-fii-pcr-kit","19":"product_tag-fvl","20":"product_tag-fvl-fii","21":"product_tag-fvl-fii-genotyping","22":"product_tag-fvl-fii-genotyping-kit","23":"product_tag-fvl-fii-genotyping-kit-ap-rad","24":"product_tag-fvl-fii-genotyping-real-time-pcr-kit","25":"product_tag-fvl-fii-kit","26":"product_tag-fvl-fii-pcr","27":"product_tag-fvl-fii-pcr-kit","28":"product_tag-fvl-fii-real-time-pcr-kit","29":"product_tag-fvl-genotyping-kit","30":"product_tag-fvl-kit","31":"product_tag-fvl-pcr","32":"product_tag-fvl-pcr-kit","33":"product_tag-genotyping-real-time-pcr","34":"product_tag-prothrombin-detection-kit","35":"product_tag-thrombophilia","36":"product_tag-thrombophilia-detection-kit","37":"product_tag-thrombophilia-kit","38":"product_tag-thrombosis-kit","39":"product_tag-thrombosis-risk","40":"product_tag-thrombosis-risk-kit","41":"pa_certificates-ruo","42":"pa_rxn-25r","43":"pa_rxn-50r","45":"first","46":"instock","47":"shipping-taxable","48":"product-type-simple"},"yoast_head":"<!-- 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important SNPs associated with hereditary thrombophilia: G506A in the FVL gene (Factor V Leiden) and G20210A in the FII gene (Prothrombin).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ap-rad.com\/product\/fvl-fii-genotyping-real-time-pcr-kit\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0634\u0631\u06a9\u062a \u067e\u0698\u0648\u0647\u0634 \u0648 \u062a\u0648\u0633\u0639\u0647 \u0627\u0645\u06cc\u0631 \u067e\u06cc\u0648\u0646\u062f\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ap-rad.com\/wp-content\/uploads\/2025\/05\/FVL-FIl-APFVIIK1.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"2206\" \/>\n\t<meta property=\"og:image:height\" content=\"2206\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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