{"id":13681,"date":"2024-12-20T18:48:07","date_gmt":"2024-12-20T15:18:07","guid":{"rendered":"https:\/\/ap-rad.com\/product\/pmlrara-fusion-detection-kit\/"},"modified":"2024-12-20T18:48:07","modified_gmt":"2024-12-20T15:18:07","slug":"pmlrara-fusion-detection-kit","status":"publish","type":"product","link":"https:\/\/ap-rad.com\/en\/product\/pmlrara-fusion-detection-kit\/","title":{"rendered":"PML::RARA Fusion Detection Kit"},"content":{"rendered":"<h3>PML::RARA Fusion Detection rRT-PCR Kit (Real-time) | PML::RARA Fusion Detection Kit<\/h3>\n<p>The chromosomal translocation t(15;17), which results in the fusion of the PML gene on chromosome 15 with the RARA gene on chromosome 17, is the cause of Acute Promyelocytic Leukemia (APL). APL is a subtype of Acute Myeloid Leukemia (AML \u2013 morphology M3) and is considered one of the most dangerous types of leukemia because it is associated with severe coagulation disorders and, without rapid diagnosis, can lead to early patient death.<\/p>\n<p>Rapid and accurate diagnosis of this disease plays a vital role in reducing mortality; as timely initiation of specific treatments such as ATRA and arsenic trioxide can transform APL from a potentially fatal condition into one of the most treatable types of leukemia.<\/p>\n<p>The PML::RARA fusion can produce three different isoforms depending on the breakpoint location in the PML gene:<\/p>\n<ul>\n<li>bcr1 (PML::RARA L \u2013 Long): Breakpoint in intron 6<\/li>\n<li>bcr2 (PML::RARA V \u2013 Variant): Breakpoint in exon 6<\/li>\n<li>bcr3 (PML::RARA S \u2013 Short): Breakpoint in intron 3<\/li>\n<\/ul>\n<p>Accurate identification of these isoforms holds great value in molecular interpretation, disease monitoring (MRD), and treatment decision-making.<\/p>\n<p>ap-rad, utilizing proprietary design and Real-Time PCR technology, has produced the PML::RARA Fusion Detection rRT-PCR Kit. This kit is designed and manufactured with the following objectives:<\/p>\n<ul>\n<li>Rapid, sensitive, and specific detection of the PML::RARA fusion<\/li>\n<li>Precise differentiation of the three isoforms bcr1, bcr2, and bcr3<\/li>\n<li>Application in initial diagnosis, molecular confirmation of APL, and monitoring treatment response<\/li>\n<\/ul>\n<p>It is considered a reliable tool for specialized molecular diagnostic laboratories in the field of hematology.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li>Performed in a one-step reaction (no need for cDNA synthesis)<\/li>\n<li>100% diagnostic sensitivity and specificity<\/li>\n<li>Contains internal, positive, and negative controls to confirm the extraction process and PCR test<\/li>\n<li>Results obtained in the shortest possible time (90 minutes)<\/li>\n<li>Differential detection of bcr1, bcr2, and bcr3 isoforms of the PML:RARA fusion in three reactions<\/li>\n<\/ul>\n","protected":false},"featured_media":13677,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"en_name":"","footnotes":""},"product_brand":[],"product_cat":[2485],"product_tag":[4058,4052,4057,2655,2566,3973,2683,4053,4059,2567,4045,4046,4044,3894,4043,3893,3907,4049,4050,4054,4047,4056,4048,4060,3906,4055,4051],"class_list":{"0":"post-13681","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-genomic-kits","7":"product_tag-acute-myeloid-leukemia-aml","8":"product_tag-acute-promyelocytic-leukemia","9":"product_tag-acute-promyelocytic-leukemia-apl","10":"product_tag-amir-peyvand","11":"product_tag-amirpeyvand","12":"product_tag-aml","13":"product_tag-ap-rad-3","14":"product_tag-apl","15":"product_tag-apl-diagnosis","16":"product_tag-aprad","17":"product_tag-bcr1","18":"product_tag-bcr2","19":"product_tag-one-step-qualitative-rt-pcr-kit-t1517-pml-rara-fusion-detection","20":"product_tag-pml-rara","21":"product_tag-pml-rara-fusion-detection-rrt-pcr-kit","22":"product_tag-pmlrara","23":"product_tag-pmlrara-detection","24":"product_tag-pmlrara-detection-kit-2","25":"product_tag-pmlrara-fusion","26":"product_tag-pmlrara-fusion-gene","27":"product_tag-pmlrara-fusion-kit","28":"product_tag-pmlrara-fusion-real-time-pcr-kit","29":"product_tag-pmlrara-fusion-rrt-pcr-kit","30":"product_tag-pmlrara-gene-fusion-test","31":"product_tag-pmlrara-pcr-kit","32":"product_tag-pmlrara-real-time-pcr","33":"product_tag-pmlrara-rrt-pcr","34":"pa_certificates-iuo","35":"pa_rxn-25r","37":"first","38":"instock","39":"sold-individually","40":"shipping-taxable","41":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v26.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>PML-RARA Fusion Detection Kit - ap-rad<\/title>\n<meta name=\"description\" content=\"The chromosomal translocation t(15;17), which results in the fusion of the PML gene on chromosome 15 with the RARA gene on chromosome 17, is the cause of Acute Promyelocytic Leukemia (APL)...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ap-rad.com\/product\/pml-rara-fusion-detection-rrt-pcr-kit\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PML::RARA Fusion Detection Kit\" \/>\n<meta property=\"og:description\" content=\"The chromosomal translocation t(15;17), which results in the fusion of the PML gene on chromosome 15 with the RARA gene on chromosome 17, is the cause of Acute Promyelocytic Leukemia (APL)...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ap-rad.com\/product\/pml-rara-fusion-detection-rrt-pcr-kit\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0634\u0631\u06a9\u062a \u067e\u0698\u0648\u0647\u0634 \u0648 \u062a\u0648\u0633\u0639\u0647 \u0627\u0645\u06cc\u0631 \u067e\u06cc\u0648\u0646\u062f\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ap-rad.com\/wp-content\/uploads\/2024\/12\/APC_0268-Large.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"1280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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