Description
Jak2 V617F Mutation Qualitative Detection Real-Time PCR | JAK2 V617F Mutation Detection Kit by Real-Time PCR
The Jak2 V617F Mutation Qualitative Detection Real-Time PCR kit, a product of ap-rad, is an accurate and rapid tool for the qualitative detection of the V617F point mutation in the JAK2 gene. This mutation is considered one of the most important molecular markers in Myeloproliferative Neoplasms (MPNs) such as Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF).
Using Real-Time PCR technology, this kit can accurately detect even very low amounts of mutated DNA and is designed for molecular diagnostic laboratories, research centers, and specialized hematology clinics.
Features and Advantages:
- High sensitivity and specificity in detecting the JAK2 V617F mutation
- Qualitative method to determine the presence or absence of the mutation
- Uses TaqMan Probe technology for greater accuracy
- Suitable for peripheral blood or bone marrow samples
- Includes positive and negative controls to ensure result accuracy
- Fast, accurate, and reliable results
Applications:
- Molecular diagnosis of Myeloproliferative Neoplasms (MPNs)
- Assisting in treatment decisions for patients with PV, ET, PMF
- Use in genetic research and molecular studies
The Jak2 V617F mutation is a signaling driver for Myeloproliferative Neoplasms (MPNs), associated with the proliferation and activation of the three main myeloid lineages (erythroid, granulocytic, and megakaryoblastic). The V617F mutation site is located on exon 14 of chromosome 9, leading to an amino acid change from valine to phenylalanine at position 617. This change makes hematopoietic cells more sensitive to factors like erythropoietin and thrombopoietin. The JAK2 V617F mutation has significant diagnostic, prognostic, and therapeutic importance. Quantitative detection of this mutation is useful for monitoring patients as a residual disease marker. The Jak2 V617F Mutation Qualitative Detection Real-Time PCR Kit from ap-rad is designed and manufactured for the rapid, sensitive, and specific detection of the JAK2 V617F mutation.
