Description

Jak2 V617F Mutation Detection Kit

Jak2 V617F Mutation Detection Kit is a specialized product from Amir Peyvand Research and Development Company designed for the qualitative identification of the V617F point mutation in the JAK2 gene. This mutation is one of the most important molecular markers in myeloproliferative disorders such as Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF).

This kit uses the Allele-Specific Amplification PCR (AS-PCR) technique to provide a rapid, accurate, and reliable detection of the Jak2 V617F mutation in DNA samples.

The kit includes all necessary components for performing 24 PCR reactions and is suitable for use in molecular diagnostic laboratories and research centers.

Features:
High sensitivity and specificity for V617F mutation detection
Accurate and stable performance under various laboratory conditions
Custom design for both research and clinical applications
The Jak2 V617F mutation is a signaling driver for Myeloproliferative Neoplasms (MPNs) associated with the proliferation and activation of three major myeloid lineages (erythroid, granulocytic, and megakaryoblastic). The V617F mutation is located on exon 14 of chromosome 9, resulting in the substitution of valine by phenylalanine at position 617. This causes hematopoietic cells to become more sensitive to factors such as erythropoietin and thrombopoietin.

Jak2 V617F mutation holds significant diagnostic, prognostic, and therapeutic value. Quantitative detection of this mutation is useful for monitoring patients as a residual disease marker. With the Amir Peyvand Research and Development Company’s kit, you can perform your molecular tests with confidence in result accuracy and time efficiency.