PML::RARA Detection rRT-PCR Kit

PML::RARA Detection rRT-PCR Kit | PML::RARA Detection Kit by rRT-PCR Method

The chromosomal translocation t(15;17), which results in the fusion of the PML gene on chromosome 15 with the RARA gene on chromosome 17, is the cause of Acute Promyelocytic Leukemia (APL). APL is a subtype of Acute Myeloid Leukemia (AML) with M3 cytomorphology and is recognized as one of the highest-risk types of AML. If not diagnosed and treated promptly, it is associated with a high risk of mortality due to severe coagulopathies. Therefore, accuracy and speed in diagnosing this disease are of vital importance. The timely initiation of effective treatments can transform APL from a very high-risk malignancy into one of the most treatable types of leukemia.

Depending on the location of the breakpoint in the PML gene (intron 6, exon 6, or intron 3), the PML::RARA fusion can occur in three different isoforms: bcr1 (PML::RARA L or Long), bcr2 (PML::RARA V or Variant), and bcr3 (PML::RARA S or Short). Accurate identification of these isoforms is important in disease diagnosis and monitoring.

ap-rad, with the aim of rapid, sensitive, and specific detection of the PML::RARA fusion and the simultaneous differentiation of bcr1, bcr2, and bcr3 isoforms, has designed and manufactured the PML::RARA Detection rRT-PCR Kit. This kit provides an efficient tool for the early diagnosis and clinical management of patients with APL.